Note : Use with caution in young children (particularly those not toilet trained) senna may cause perianal skin breakdown and blistering if the stool is left in contact with the skin for a prolonged time and/or if high doses are administered (Cogley 2017 Vilanova-Sanchez 2018).Ĭhildren 2 to <6 years: Oral: 2.5 to 3.75 mL (4.4 to 6.6 mg sennosides) at bedtime maximum daily dose: 3.75 mL (6.6 mg sennosides) twice daily. Stimulant laxatives (eg, senna) may be used as additional or second-line therapy for short-term use (NASPGHAN ).Ĭhildren <2 years: Very limited data available: Oral: 1.25 to 2.5 mL (2.2 to 4.4 mg sennosides) per day maximum daily dose: 5 mL (8.8 mg sennosides) per day (Blackmer 2010). Note: Other agents (eg, polyethylene glycol 3350) are preferred for constipation maintenance therapy. Senna leaf extract syrup (176 mg/5 mL senna leaf extract): Note: Senna leaf extract is considered a dietary supplement and is not interchangeable on a mL-to-mL (or mg-to-mg) basis with other senna products that contain sennosides.ġ0 to 15 mL (352 to 528 mg senna leaf extract) once daily (preferably at bedtime) may increase to 10 to 15 mL (352 to 528 mg senna leaf extract) twice daily if needed maximum daily dose: 30 mL/ day 2017 6(2): 349-353.Syrup (8.8 mg sennosides/5 mL): 10 to 15 mL (17.6 mg to 26.4 mg sennosides) once daily maximum: 15 mL (26.4 mg sennosides) twice daily.Ĩ.6 mg sennosides/tablet: Two tablets (17.2 mg sennosides) once daily maximum: 4 tablets (34.4 mg sennosides) twice dailyġ5 mg sennosides/tablet: Two tablets (30 mg sennosides) once or twice dailyġ7.2 mg sennosides/tablet: One tablet (17.2 mg sennosides) once daily maximum: 2 tablets (34.4 mg sennosides) twice dailyĢ5 mg sennosides/tablet: Two tablets (50 mg sennosides) once or twice daily Journal of Pharmacognosy and Phytochemistry. Recent Advances on Senna as a Laxative: A Comprehensive Review. Effect of dietary fiber on constipation: a meta analysis. Senna treatment in pregnant women and congenital abnormalities in their offspring-a population-based case-control study. Acute liver failure with renal impairment related to the abuse of senna anthraquinone glycosides. Vanderperren B, Rizzo M, Angenot L, Haufroid V, Jadoul M, Hantson P. Evidence-based clinical practice guidelines for irritable bowel syndrome 2020. Anti-inflammatory, laxative and intestinal motility effects of Senna macranthera leaves. Guarize L, Costa JC, Dutra LB, Mendes RF, Lima IV, Scio E. Addition of senna improves quality of colonoscopy preparation with magnesium citrate. Vradelis S, Kalaitzakis E, Sharifi Y, et al. Chronic constipation: current treatment options. Efficacy and Safety of Over-the-Counter Therapies for Chronic Constipation: An Updated Systematic Review.
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